Antibiotic Potential of Marine Actinomycetes of the Genera <i>Streptomyces</i> and <i>Nocardiopsis</i>

Due to the emergence of antibiotic resistance in pathogenic microorganisms, it is urgent search for producers new antimicrobial metabolites. Actinomycetes are gram-positive mycelial bacteria that produce a large number antibiotics used medicine and agro-industrial complex. Currently, researchers focused on actinomycetes ecological niches such as freshwater marine reservoirs, zones with extreme natural conditions (permafrost soils, glaciers, desert, saline etc.). In this study, cultures were restored after 15 years storage under vaseline oil. It was shown all strains retained viability activity at high level. Based results 16S rRNA gene sequence analysis, species identified as: Streptomyces sampsonii 6N, 8N, 521N, halstedii 22N, brevispora 12N, hirsutus 23N, niveus 14N, Nocardiopsis alba 24N, 73N, 85N, 106N, alborubida 722N, umidischolae 755N, 763N. These actinobacteria possessed significant against following pathogens: Micrococcus luteus ATCC 9341, Staphylococcus aureus INA 00985, Bacillus subtilis 6633, 00761 (MRSA — ), Escherichia coli 25922, Pseudomonas aeruginosa 27853, Pectobacterium carotovorum VKM-B1247, Saccharomyces cerevisiae 01042, Candida albicans 14053, Aspergillus niger 16404, fumigatus CPB F -37, Fusarium solani VKPM F-890, oxysporum F-148. Therefore, study evaluated can be potential novel antibiotics.